Purity 99% Min CMIT/MIT 26172-55-4 Spot Supply with Safe Transportation
- Molecular Formula:C4H4ClNOS
- Molecular Weight:149.601
- Appearance/Colour:Clear to yellow liquid
- Vapor Pressure:0.328mmHg at 25°C
- Melting Point:42-45?C
- Refractive Index:n20/D 1.378
- Boiling Point:200.2 °C at 760 mmHg
- PKA:-4.06±0.40(Predicted)
- Flash Point:74.9 °C
- PSA：50.24000
- Density:1.51 g/cm3
- LogP:1.10020
Isothiazolinones(Cas 26172-55-4) Usage
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Safety Information |
The recommended use of isothiazolinone products by the manufacturers used as wrinkle releaser is not harmful. However, allergy to skin is one of the most reported issue with isothiazolinone. |
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Applications |
Although isothiazolinones have no direct applications, their derivatives such as 5-chloro-2-methyl-4-isothiazolin-3-on and 2-methyl-4-isothiazolin-3 which are used together as preservatives in commercial households and cosmetics products, for instance, cleaners, shampoos, and washing materials. Notably, various products that use isothiazolinones are in the market, including shampoo, hand sanitizer, and lotions. Isothiazolinones is used in these products as an inhibitor of microbial activity that could lead to the product spoiling before the expected expiration date. |
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Definition |
ChEBI: A 1,2-thiazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom and a chlorine at C-5. It is a powerful biocide and preservative and is the major active ingredient in the commercial product KathonTM. |
InChI:InChI=1/C4H4ClNOS.ClH/c1-6-4(7)2-3(5)8-6;/h2H,1H3;1H
26172-55-4 Relevant articles
Preparation method of 2-methyl-4-isothiazoline-3-one aqueous solution
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Paragraph 0031-0044; 0048-0050, (2020/12/31)
The invention provides a preparation met...
Preparation method of 3-isothiazolinone compound
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Paragraph 0033-0039, (2020/12/31)
The invention discloses a preparation me...
Pipeline type continuous production method of 3-isothiazolinone compound
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Paragraph 0018, (2019/12/02)
The invention discloses a pipeline type ...
MICROBICIDE
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Paragraph 0065; 0067, (2016/12/07)
5-chloro-2-methyl-4-isothiazolin-3-yn as...
26172-55-4 Process route
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- 999-72-4
N,N'-dimethyl-3,3'-dithiodipropionamide
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- 26172-55-4
5-chloro-2-methyl-2H-isothiazol-3-one
| Conditions | Yield |
|---|---|
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With chlorine; potassium iodide; In ethyl acetate; at 40 - 55 ℃; for 0.25h;
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95% |
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With sulfuryl dichloride; In 1,2-dichloro-ethane;
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|
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N,N'-dimethyl-3,3'-dithiodipropionamide; With chlorine; In water; ethyl acetate;
With hydrogenchloride; magnesium(II) nitrate hexahydrate; magnesium oxide; In water; ethyl acetate; toluene; at 40 - 80 ℃; for 3h; pH=1 - 4; Solvent;
|
-
- 999-72-4
N,N'-dimethyl-3,3'-dithiodipropionamide
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- 26172-55-4
5-chloro-2-methyl-2H-isothiazol-3-one
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- 2682-20-4
2-methyl-3-isothiazolone
| Conditions | Yield |
|---|---|
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With thionyl chloride; In 1,2-dichloro-ethane; at 10 ℃; for 2h;
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56% 18% |
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With chlorine; In ethyl acetate; acetonitrile; at 5 - 10 ℃; for 1h; Solvent; Temperature; Overall yield = 85 percent;
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26172-55-4 Upstream products
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999-72-4
N,N'-dimethyl-3,3'-dithiodipropionamide
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1003-07-2
3-oxo-2,3-dihydroisothiazole
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107-06-2
1,2-dichloro-ethane
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52334-99-3
N-methyl-3-mercaptopropionamide
26172-55-4 Downstream products
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26530-20-1
2-octyl-isothiazol-3-one
2254784343