What is 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone (530084-79-8) used for?

8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone is a light brown solid with a complex chemical structure. It is a derivative of quinolinone, a heterocyclic compound with potential applications in various fields due to its unique properties.InChI:InChI=1/C18H16BrNO3/c19-10-15(21)13-6-8-16(18-14(13)7-9-17(22)20-18)23-11-12-4-2-1-3-5-12/h1-9,15,21H,10-11H2,(H,20,22)/t15-/m0/s1

What is 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone (530084-79-8) used for?

8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone is a light brown solid with a complex chemical structure. It is a derivative of quinolinone, a heterocyclic compound with potential applications in various fields due to its unique properties.InChI:InChI=1/C18H16BrNO3/c19-10-15(21)13-6-8-16(18-14(13)7-9-17(22)20-18)23-11-12-4-2-1-3-5-12/h1-9,15,21H,10-11H2,(H,20,22)/t15-/m0/s1

530084-79-8

(R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one

Q: What is the 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone?

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone is , while it's Molecular Formula is C18H16BrNO3. 8-Benzyloxy-5-((R)-2-bromo-1-hydroxyethyl)-1H-quinolinone is used in the preparation of phenylethanolamine derivatives as β2 adrenoreceptor agonists.

Q: What is the CAS number for 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone?

The CAS number of 8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone is 530084-79-8.

別名：

CasNo.： 530084-79-8

分子式： C₁₈H₁₆BrNO₃

分子量： 374.234

儲存條件：

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中文名稱： (R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one

英文名稱： (R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one

CasNo.： 530084-79-8

分子式： C₁₈H₁₆BrNO₃

分子量： 374.234

Purity 99% Min (R)-8-(Benzyloxy)-5-(2-bromo-1-hydroxyethyl)quinolin-2(1H)-one 530084-79-8 Spot Supply with Safe Transportation

Molecular Formula:C18H16BrNO3
Molecular Weight:374.234
Vapor Pressure:0mmHg at 25°C
Refractive Index:1.649
Boiling Point:595.764 °C at 760 mmHg
PKA:10.78±0.70(Predicted)
Flash Point:314.107 °C
PSA：62.32000
Density:1.491 g/cm³
LogP:3.53540

8-Benzyloxy-5-((R)-2-broMo-1-hydroxyethyl)-1H-quinolinone(Cas 530084-79-8) Usage

InChI:InChI=1/C18H16BrNO3/c19-10-15(21)13-6-8-16(18-14(13)7-9-17(22)20-18)23-11-12-4-2-1-3-5-12/h1-9,15,21H,10-11H2,(H,20,22)/t15-/m0/s1

530084-79-8 Relevant articles

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Rancati, Fabio,Linney, Ian D.,Rizzi, Andrea,Delcanale, Maurizio,Knight, Chris K.,Schmidt, Wolfgang,Pastore, Fiorella,Riccardi, Benedetta,Mileo, Valentina,Carnini, Chiara,Cesari, Nicola,Blackaby, Wesley P.,Patacchini, Riccardo,Carzaniga, Laura

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CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE

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Paragraph 0160, (2019/11/11)

The invention provides a class of compou...

8 - Benzyloxy -5 - (R - 2 - bromo -1 - hydroxy-ethyl) - 1H - quinoline -2 - ketone

-

Paragraph 0021; 0022; 0024, (2019/01/08)

The present invention relates to 8 - ben...

530084-79-8 Process route

: 100331-89-3
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one

: 530084-79-8
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

Conditions

Conditions	Yield
With (S,S)-1,2-diphenyl-1,2-diaminoethane; hydrogen; potassium hydroxide; In isopropyl alcohol; at 25 ℃; under 3800.26 Torr; Solvent; Pressure; Temperature; Autoclave; Inert atmosphere;	99%
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at 0 - 30 ℃; Inert atmosphere; With hydrogenchloride; In tetrahydrofuran; at 0 - 30 ℃;	95%
With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at 0 - 10 ℃; Inert atmosphere;	95%
With dimethylsulfide borane complex; (1R,2S)-1-Amino-2-indanol; In tetrahydrofuran; at 20 - 25 ℃; for 3.5h; Inert atmosphere;	85.5%
With Trimethylboroxine; (R)-α,α-diphenylprolinol; In toluene; at 20 - 150 ℃; 8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With borane; In tetrahydrofuran; toluene; at -10 ℃; for 4.75h; With methanol; In tetrahydrofuran; toluene; at -10 ℃;	81%
With borane; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at -10 ℃; for 4.75h;	81%
(R)-α,α-diphenylprolinol; With Trimethylboroxine; In toluene; at 20 - 150 ℃; for 4.5h; 8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With borane; In tetrahydrofuran; toluene; at -10 ℃; for 4.75h;	81%
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With borane-THF; In toluene; at -10 ℃; for 4.75h; Cooling with isopropanol-ice; With methanol; In toluene;	81%
With Trimethylboroxine; (R)-α,α-diphenylprolinol; In toluene; at 20 - 150 ℃; for 4.5h; 8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With trimethylborane; In tetrahydrofuran; toluene; at -15 - -5 ℃; for 4.75h; Cooling with ice-isopropanol;	81%
With borane; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at -10 - 5 ℃; for 4.75h;	81%
Trimethylboroxine; (R)-α,α-diphenylprolinol; In toluene; at 20 - 150 ℃; for 4.5h; 8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With borane; In tetrahydrofuran; methanol; toluene; at -15 - -5 ℃; for 4.75h; Cooling with ice/isopropanol bath;	81%
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With Trimethylboroxine; borane; (R)-α,α-diphenylprolinol; In tetrahydrofuran; toluene; acetonitrile; at -15 - 20 ℃; for 5.25h; With methanol; In tetrahydrofuran;	81%
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at -20 ℃; for 4h; Inert atmosphere; With methanol; In tetrahydrofuran; toluene; at -20 - 20 ℃; for 0.333333h; With hydrogenchloride; In water; at 20 ℃; for 18h;	76%
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With dimethylsulfide borane complex; In tetrahydrofuran; toluene; at -20 ℃; for 3h; Inert atmosphere; With methanol; In tetrahydrofuran; toluene; at 20 ℃; for 0.333333h; With hydrogenchloride; In water; at 20 ℃; for 18h;	76%
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at -20 - 20 ℃; for 4.33333h; Inert atmosphere; With hydrogenchloride; In water; at 20 ℃; for 18h;	76%
With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at -20 ℃; for 4h;	76%
With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at -20 - 20 ℃; Inert atmosphere;	76%
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at -20 ℃; Inert atmosphere; With dimethyl sulfide borane; In tetrahydrofuran; toluene; at -20 ℃; for 4h; Inert atmosphere;	76%
With borane dimethyl sulfide complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at -20 ℃; for 4h; Inert atmosphere;	76%
With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at -20 ℃; for 4h; Inert atmosphere;	76%
With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at -20 ℃; Inert atmosphere;	76%
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With dimethylsulfide borane complex; Trimethylboroxine; (R)-α,α-diphenylprolinol; In tetrahydrofuran; toluene; at -6 - -5 ℃; for 3.5h; With methanol; In tetrahydrofuran; toluene; at -5 - 0 ℃; for 0.5h;
With borane-THF; Trimethylboroxine; (R)-α,α-diphenylprolinol; In tetrahydrofuran; toluene; at -10 ℃; for 4.75h;	95 % ee
With borane; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at -5 ℃; for 3.75h;
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at -55 - -45 ℃; for 0.666667h; Inert atmosphere; With borane-THF; In tetrahydrofuran; at -45 - 0 ℃; Inert atmosphere; With methanol; In tetrahydrofuran; at 20 ℃;
With formic acid; C₂₅H₂₉ClN₂O₃RuS; potassium formate; In chloroform; at 25 ℃; for 24h; enantioselective reaction; Inert atmosphere;	94 % ee
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; In tetrahydrofuran; at 40 ℃; for 48h; With borane-THF; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at -10 - 0 ℃; for 4.5h;
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one; With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at 0 - 2 ℃; for 3.25 - 3.33333h; With methanol; In tetrahydrofuran; toluene; for 0.25 - 0.333333h;

: 100331-89-3
8-benzyloxy-5-bromoacetylcarbostyril

: 112022-83-0,133261-83-3
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole

: 530084-79-8
8-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]quinolin-2(1H)-one

Conditions

Conditions	Yield
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; With dimethyl sulfide borane; In tetrahydrofuran; at 0 ℃; for 0.166667h; 8-benzyloxy-5-bromoacetylcarbostyril; In tetrahydrofuran; at -10 ℃; for 0.333333h; With dimethyl sulfide borane; at 0 ℃; for 5h;

530084-79-8 Upstream products

100331-89-3
8-benzyloxy-5-(2-bromoacetyl)-1H-quinolin-2-one
100331-89-3
8-benzyloxy-5-bromoacetylcarbostyril
112022-83-0
(3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole
1127-45-3
8-Hydroxyquinoline-N-oxide

530084-79-8 Downstream products

662111-14-0
8-(benzyloxy)-5-[(1R)-2-bromo-1-(tetrahydro-2H-pyran-2-yloxy)ethyl]quinolin-2(1H)-one
530084-74-3
(R)-8-(benzyloxy)-5-(2-bromo-1-((tert-butyldimethylsilyl)oxy)ethyl)quinolin-2(1H)-one
173140-90-4
(R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone
1254097-58-9
4-({[5-(2-{[4-({[(2R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino}methyl)phenyl]carbamoyl}ethyl)-2-phenylphenyl]carbamoyl}oxy)-1,1-dimethylpiperidin-1-ium trifluoroacetate