4-(4-fluoro-phenyl)-3-oxo-butyric acid ethyl ester
4-(4-fluoro-phenyl)-3-oxo-butyric acid ethyl ester
Cosmetics Grade 4-(4-fluoro-phenyl)-3-oxo-butyric acid ethyl ester 221121-37-5 For Sale with Good Price
- Molecular Formula:C12H13FO3
- Molecular Weight:224.232
- Vapor Pressure:0.002mmHg at 25°C
- Refractive Index:1.493
- Boiling Point:295.509 °C at 760 mmHg
- PKA:10.35±0.46(Predicted)
- Flash Point:128.353 °C
- PSA：43.37000
- Density:1.161 g/cm3
- LogP:1.89050
4-(4-FLUORO-PHENYL)-3-OXO-BUTYRIC ACID ETHYL ESTER(Cas 221121-37-5) Usage
InChI:InChI=1/C12H13FO3/c1-2-16-12(15)8-11(14)7-9-3-5-10(13)6-4-9/h3-6H,2,7-8H2,1H3
221121-37-5 Relevant articles
Discovery of pyrrolo[2,3-d]pyrimidine derivatives as potent Axl inhibitors: Design, synthesis and biological evaluation
Xu, Dandan,Sun, Deqiao,Wang, Wei,Peng, Xia,Zhan, Zhengsheng,Ji, Yinchun,Shen, Yanyan,Geng, Meiyu,Ai, Jing,Duan, Wenhu
, (2021/05/06)
Axl has emerged as an attractive target ...
Non-metal Lewis acid-catalyzed cross-Claisen condensation for β-keto esters
Han, Zhengyu,Huang, Hai,Meng, Fuliang,Yang, Zhenkun,Zhang, Tianyu,Zhou, Dapeng
supporting information, p. 9163 - 9166 (2021/11/16)
In this work, we disclose a new catalyti...
PYRIDONE COMPOUNDS AND METHODS OF USE IN THE MODULATION OF A PROTEIN KINASE
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Paragraph 0263, (2021/04/02)
The present disclosure relates generally...
MACROCYCLIC FUSED PYRRAZOLES AS MCL-1 INHIBITORS
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Paragraph 0851, (2020/08/13)
Provided are compounds represented by Fo...
221121-37-5 Process route
-
- 2033-24-1
cycl-isopropylidene malonate
-
- 459-04-1
4-Fluorophenylacetyl chloride
-
- 221121-37-5
4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester
| Conditions | Yield |
|---|---|
|
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h;
|
86.8% |
|
With pyridine; In dichloromethane; at 0 ℃;
|
37% |
|
With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
|
8.5 g |
-
- 2033-24-1
cycl-isopropylidene malonate
-
- 64-17-5
ethanol
-
- 459-04-1
4-Fluorophenylacetyl chloride
-
- 221121-37-5
4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester
| Conditions | Yield |
|---|---|
|
cycl-isopropylidene malonate; 4-Fluorophenylacetyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 4h;
ethanol; for 2h; Heating;
|
87% |
|
cycl-isopropylidene malonate; 4-Fluorophenylacetyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 3h;
ethanol; In dichloromethane; Reflux;
|
86.8% |
|
cycl-isopropylidene malonate; ethanol; 4-Fluorophenylacetyl chloride; With pyridine; In dichloromethane; at 0 - 20 ℃; for 5h; Inert atmosphere;
In ethanol; dichloromethane; at 80 ℃; for 4h; Inert atmosphere;
|
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